This figure summarizes the outcomes following ultrasound stimulation. Low-intensity brainwave-like pattern ultrasound stimulation sequentially stimulates TRPA1 in astrocytes, leading to BEST1-dependent neurotransmitter secretion. This, in turn, stimulates adjacent neurons, inducing neural plasticity in the neurons. This process briefly describes how changes in cognitive functions associated with pattern-dependent memory and learning, as well as changes in behavioral aspects, become evident. Credit: Institute for Basic Science
Institute for Basic Science
Feb. 23, 2024
The human brain's adaptability to internal and external changes, known as neural plasticity, forms the foundation for understanding cognitive functions like memory and learning, as well as various neurological disorders.
New research conducted by a team led by Dr. Park Joo Min of the Center for Cognition and Sociality within the Institute for Basic Science (IBS) unveils a novel technique that could transform the treatment landscape for brain disorders. The work has been published in Science Advances.
The team developed a non-invasive brain stimulation method called Patterned Low-Intensity Low-Frequency Ultrasound (LILFUS) that holds tremendous potential for inducing long-lasting changes in brain function.
Traditionally, magnetic and electrical brain stimulation methods have been used to modulate brain function. However, these methods come with inherent limitations that restrict their spatial resolution and penetration depth, making it challenging to precisely stimulate specific brain regions with optimal efficacy.
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