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Accidental Fungus Leads To Promising Cancer Drug (Maggie Fox) PDF Print
 

By Maggie Fox, on 01-07-2008 08:45

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A Lodamin nanoparticle with TNP-470 (the drug's active ingredient) at the core, protected by two short polymers (PEG and PLA) that allow TNP-470 to be absorbed intact when taken orally is seen in an undated handout illustration.

  (Reuters) -- A drug developed using nanotechnology and a fungus that contaminated a lab experiment may be broadly effective against a range of cancers, U.S. researchers reported Sunday.

  The drug, called lodamin, was improved in one of the last experiments overseen by Dr. Judah Folkman, a cancer researcher who died in January. Folkman pioneered the idea of angiogenesis therapy -- starving tumors by preventing them from growing blood supplies.

  Lodamin is an angiogenesis inhibitor that Folkman's team has been working to perfect for 20 years. Writing in the journal Nature Biotechnology, his colleagues say they developed a formulation that works as a pill, without side-effects.

  They have licensed it to SynDevRx, Inc, a privately held Cambridge, Massachusetts biotechnology company that has recruited several prominent cancer experts to its board.

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Last update : 01-08-2008 18:12

   
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Keywords : biotechnology, massachusetts, angiogenesis, experiments, formulation, colleagues, preventing, researcher, cambridge, developed, folkman's, inhibitor, pioneered, privately, prominent, recruited, improved, licensed, overseen, starving, supplies, syndevrx, effects, experts, folkman,


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